2020 Medicinal Chemistry Reviews

Volume 55, Chapter 22
Therapeutic Degradation of Protein Kinases Through PROTACs: Current Status and Future Potential
Li Zhang, Campbell McInnes

1. Introduction
2. Ubiquitin-Proteasome System (UPS) and Protein Degradation
3. PROteolysis TArgeting Chimeras (PROTACs) Targeting Protein Kinases
4. Conclusions

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