2020 Medicinal Chemistry Reviews

Volume 55, Chapter 21
Design Strategies for Second-Generation Irreversible Covalent Inhibitors of Bruton’s Tyrosine Kinase
Hui Qiu, Momar Toure, Rebecca L. Casaubon, Maria C. DiPoto, Roland Grenningloh, Richard D. Caldwell

1. Introduction
2. Strategies for Achieving Selectivity for Bruton’s Tyrosine Kinase
3. Second-Generation Irreversible Covalent Inhibitors Approved and in Development
4. Conclusion

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