2020 Medicinal Chemistry Reviews

Volume 55, Chapter 12
The Development of Tropomyosin Receptor Kinase (Trk) Inhibitors as Targeted Cancer Therapeutics
Abhijit Bhat, Stephane Ciblat, Hong Wang, Kollol Pal

1. Introduction
2. Structure and Function
3. Trk Biology in Cancer
4. Trk Inhibitors in Cancer
5. Approved Trk Inhibitors and Outlook on Next-Generation Molecules
6. Future Directions

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