2019 Medicinal Chemistry Reviews

Volume 54, Chapter 10
The Discovery of Manogepix/Fosmanogepix and Other Gwt1 Inhibitors for the Treatment of Invasive Fungal Infections
Jonathan A. Covel, Quinlyn A. Soltow, Mili Kapoor, Molly K. Moloney, Peter J. Webb, Michael Trzoss, Marc Sharp, Karen Joy Shaw

1. Introduction
2. Glycosylphosphatidylinositol Anchor Biosynthesis and Function
3. Gwt1 Inhibitor Chemotypes
4. Optimization of BIQ to Manogepix (APX001A)
5. In Vitro and In Vivo Profile of Manogepix/Fosmanogepix
6. Manogepix Analogs with Improved Activity Against Cryptococcus
7. Conclusion

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