2018 Medicinal Chemistry Reviews

Volume 53, Chapter 5

Recent Progress in Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors for the Treatment of Parkinson's Disease

Douglas S. Williamson, Morten Jørgensen and Kenneth V. Christensen

1.  Introduction                           67

2.  Discovery of Key Compounds   68

     2.1  Aminopyrimidines            69

     2.2  Pyrrolopyrimidines           70

     2.3  Indazoles                        71

3.  Structural Biology                   72

4.  Clinical Progress                     76

5.  Conclusions                            77

To purchase a copy, contact secretary@acsmedchem.org

ACS Division of Medicinal Chemistry

Webmaster:  secretary@acsmedchem.org