Medicinal Chemistry Reviews

Volume 52, Chapter 18

Endogenous Allosteric Modulators of G Protein-Coupled Receptors:  Implications in Drug Design

Dario Doller

1.          Introduction                                                                                                               343

2.         Oligomers                                                                                                                   344

3.         Ions                                                                                                                             348

4.         Peptides                                                                                                                     351

5.         Amino Acids                                                                                                               352

6.         Purinergic Nucleotides                                                                                              353

7.         Carbohydrates                                                                                                           353

8.         Lipids                                                                                                                          354

9.         Metabolites of Orthosteric Ligands                                                             355

10.        Summary: Implications in Drug Design                                                                   357

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