Medicinal Chemistry Reviews

Volume 52, Chapter 16

Capsid Assembly Modulators as Novel Antiviral Agents for the Treatment of Hepatitis B

Scott D. Kuduk and Angela M. Lam

1.          Introduction                                                                                                               305

            1.1        Hepatitis B Overview                                                                                    305

            1.2        Capsid Biology                                                                                              306

2.         Capsid Assembly Modulator Chemotypes                                                             307

            2.1        Heteroaryl Pyrimidines                                                                                 307

            2.2       Sulfonyl Carboxamides                                                                                309

            2.3       Others                                                                                                 311

3.         Mechanism of Action                                                                                                312

4.         In Vivo Preclinical Studies and Emerging Clinical Data with

Capsid Assembly Modulators                                                                                  314

5.         Concluding Remarks                                                                                     315

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