Medicinal Chemistry Reviews

Volume 50, Chapter 2
Some Thoughts on the Past 50 Years of Central Nervous System Therapeutic Research
Paul L. Ornstein

1.    Introduction                                                                                                                31

2.   Historical Perspective                                                                                                 33

3.   CNS Topics in the First Annual Reports in Medicinal Chemistry                            36

4.   Antipsychotics                                                                                                             37

5.   Antidepressants                                                                                                          39

6.   Analgesics                                                                                                                    41

7.   Sleep and Wake                                                                                                          42

8.   Anticonvulsants                                                                                                          44

9.   Excitatory Amino Acid Targeted Therapeutics                                                         45

10. Migraine                                                                                                                       46

11. Neurodegenerative Diseases                                                                                     47

12. Neuropeptides                                                                                                             49           

13. Smoking Cessation                                                                                                      50

14. Hypoactive Sexual Desire Disorder                                                                            51

15. CNS Topics in Volume 49 of Annual Reports in Medicinal Chemistry                   52

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ACS Division of Medicinal Chemistry

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