Reviews: 2020 Medicinal Chemistry Reviews

Ref. n°: REV2020

Volume : 55
Editor-In-Chief : Joanne J. Bronson

Medicinal Chemistry Reviews is an outstanding 830 page volume providing timely and critical reviews of important topics in medicinal chemistry. It is provided free of charge to MEDI members in electronic format. Members can also order a print copy, for the cost of printing, shipping and handling

Table of contents

Chapter 1Drug Discovery: Ingenuity and Serendipity...Or is It the Other Way Around?
Richard B. Silverman
Chapter 2The Making of a Drug-Hunting Addict
Scott A. Biller
Chapter 3Recent Progress in Neuroinflammatory Drug Targets
David P. Rotella
Chapter 4Recent Progress in Kappa and Mu Opioid Receptor Targeted Ligands
Michael W. Miller, Brian Reed
Chapter 5Engineered Heart Tissue: An Emerging Paradigm for Early Drug Screening
Matthew J. Robeson, Kristin M. French
Chapter 6Modulation of Soluble Guanylate Cyclase for the Treatment of Heart Failure and Related Cardiovascular Diseases
Christopher R. Jamison, Andrew K. Dilger
Chapter 7Recent Advances in the Discovery of NLRP3 Inflammasome Inhibitors
David Harrison
Chapter 8Advances in the Discovery and Development of Non-Covalent and Covalent BTK Inhibitors Targeting Autoimmune Diseases
Scott H. Watterson and Joseph A. Tino
Chapter 9TLR7, TLR8, and TLR9 Antagonists: Potential Therapies for Autoimmune Diseases
Lynn D. Hawkins
Chapter 10Clinical and pre-clinical approaches to the inhibition of KRASG12C
Brian A. Lanman, Victor J. Cee, Matthew A. Marx
Chapter 11Allosteric Inhibition of SHP2 Phosphatase
Matthew J. LaMarche
Chapter 12The Development of Tropomyosin Receptor Kinase (Trk) Inhibitors as Targeted Cancer Therapeutics
Abhijit Bhat, Stephane Ciblat, Hong Wang, Kollol Pal
Chapter 13Recent Progress in the Discovery and Clinical Application of Small-Molecule Inhibitors EZH2 and EED
Julian R. Levell
Chapter 14Quorum Sensing in Polymicrobial Infections: Analysis of Existing Small Molecule Modulators
Nadezhda A. German
Chapter 15Drug Target Residence Time and the Pharmacodynamics of Antibacterial Agents
Sneha Basak, Peter J. Tonge
Chapter 16The Drug Substances of Long-Acting Injectables: Examples from Hormone, CNS, and Antiviral Therapies
Ana Z. Gonzalez, Scott V. Jermain, Ezra B. Roberts, Gregg M. Schwarzwalder
Chapter 17Targeting Nuclear Export for Treatment of Cancers and Other Diseases
Hanmo Zhang, Dejan Maglic
Chapter 18Proteasome Activation to Restore Protein Trafficking: A Different Perspective on the Ubiquitin-Proteasome System
Bhaumik A. Pandya, Stephen J. Wood
Chapter 19RNA-Modifying Enzymes and Their Inhibitors
Wesley Peter Blackaby, Byron Andrews, Beth Thomas, David Hardick, Eric A. Miska
Chapter 20Recent Developments in IKB Kinases IKK-ε and Tank-Binding Kinase 1 (TBK1) Modulators
Amit A. Joharapurkar, Vrajesh B. Pandya, Mukul R. Jain, Ranjit C. Desai
Chapter 21Design Strategies for Second-Generation Irreversible Covalent Inhibitors of Bruton’s Tyrosine Kinase
Hui Qiu, Momar Toure, Rebecca L. Casaubon, Maria C. DiPoto, Roland Grenningloh, Richard D. Caldwell
Chapter 22Therapeutic Degradation of Protein Kinases Through PROTACs: Current Status and Future Potential
Li Zhang, Campbell McInnes
Chapter 23DNA-Encoded Libraries in the Pharmaceutical Industry
Alexander L. Satz, Christopher S. Kollmann, Brian M. Paegel
Chapter 24Case History: Tpoxx® (Tecovirimat)—A Novel Orthopoxvirus Egress Inhibitor for the Treatment of Smallpox
Robert Jordan, Doug Grosenbach, James Burgeson, Dennis Hruby
Chapter 25Case History: Eucrisa® (Crisaborole Ointment, 2%), A Boron-Based PDE4 Inhibitor for the Topical Treatment of Atopic Dermatitis
Matthew A. Perry
Chapter 26New Chemical Entities Entering Phase III Trials in 2019
Matthew L. Condakes, Anna E. Hurtley, David W. Lin, Gregory T. Notte, Vickie Tsui, Nathan E. Wright, Alec H. Christian
Chapter 27To Market, to Market—2019: Small Molecules
Erika Araujo, Catherine A. Bolger, Marie-Gabrielle Braun, Georgette Castanedo, Mingshuo Zeng, Adam K. Charnley, Antonella Converso, Izzat T. Raheem, Anthony J. Roecker, Akshay A. Shah, T. G. Murali Dhar, Denise C. Grünenfelder, J. Robert Merritt, Kevin M. Peese
Chapter 28To Market, to Market—2019: Macromolecular Therapeutics
Nicholas J. Agard, Peter S. Dragovich, Allison M. Beal, Catherine A. Bolger, Suzana A. Kahn, Brant Hubbard, Daša Lipovšek