Reviews: 2023 Medicinal Chemistry Reviews

Ref. n°: REV2023

Volume : 58
Editor-In-Chief : Joanne J. Bronson and Joachim Rudolph

Table of contents

Chapter 1My Career in Medicinal Chemistry
John A. Lowe III
Chapter 2You Can’t Always Get What You Want. But If You Try Sometimes, You Get What You Need: Insights from My Unlikely Career in Drug Development
Dennis Liotta
Chapter 35-HT2A Receptor as an Evolving Neurotherapeutic Target
Andrew A. Bolinger, Noelle C. Anastasio, Kathryn A. Cunningham, Jia Zhou
Chapter 4Recent Developments in the Discovery of Brain-Penetrant RIP1 Inhibitors
Craig E. Stivala, Domagoj Vucic
Chapter 5Advances Toward an Oral Non-Peptide Agonist of the GLP-1 Receptor
Todd Fields, Eric Woerly, Michael G. Bell, Kyle W. Sloop, and Joseph D. Ho
Chapter 6Recent Advances in Small-Molecule Inhibitors of Ketohexokinase (KHK)
David Ebner, Gregory Tesz, and Kentaro Futatsugi
Chapter 7Targeting Selective Tyrosine Kinase 2 (TYK2) Inhibitors for the Treatment of Autoimmune Diseases
Silvana Leit, Bhaskar Srivastava, Nathan E. Genung, Joshua J. McElwee, Denise Levasseur, Scott D. Edmondson
Chapter 8An Integrin Renaissance: Recent Progress of Integrin Modulators in the Clinic
Darren Finkelstein, Timothy D. Machajewski
Chapter 9Salt-inducible Kinases: An Emerging Target Class with Broad Therapeutic Potential
Nicolas Desroy, Christophe Peixoto, Steve De Vos
Chapter 10Small Molecule Degraders of Ikaros Zinc Finger (IKZF) Transcription Factors
Natalie Holmberg-Douglas, Godwin K. Kumi, Ashok V. Purandare, Hunter Shunatona
Chapter 11Recent Advances in Targeting the PRMT5/MTA Complex
Christopher R. Smith, Matthew A. Marx
Chapter 12Recent Advances in the Discovery of Cyclin-Dependent Kinase 2 (CDK2) Selective Inhibitors
Kevin D. Freeman-Cook, Robert L. Hoffman
Chapter 13Recent Advances in Synthetic Access to Antimicrobial Natural Products
M. Alejandro Valdes-Pena and Joshua G. Pierce
Chapter 14Practical Applications of Machine Learning for Anti-Infective Drug Discovery
Nishant Sarkar and Jonathan M. Stokes
Chapter 15Recent Progress in Antivirals against Zika Virus
María-Jesús Pérez-Pérez, Eva-María Priego, Miguel A. Martín-Acebes
Chapter 16Small Molecule RNA Splicing Modulators
Hasane Ratnia, Kathleen D. McCarthy, Joseph L. Duffy, Sergey V. Paushkin, Sivaraman Dandapani
Chapter 17Small-Molecule Modulators of Biomolecular Condensates
George S. Tria, Joseph W. Tucker, Mary E. Spilker, Brooke A. Conti, Mariano Oppikofer
Chapter 18The Rise, Fall, and Future Promise of IDO1 Inhibitors for Immuno-Oncology
Emily Cherney, Susheel J. Nara, David Williams, Liping Zhang
Chapter 19Drug-Induced Liver Injury: Mechanisms, Methods for Pre-Clinical Assessment and a Medicinal Chemist’s Perspective
Anh T. Tran, James J. Crawford, Debashis Mandal, Tezcan Guney, Jamie Karmel
Chapter 20Non-cyclic Dinucleotide STING Agonists for Immuno-Oncology
Julian Lo, Emily Cherney
Chapter 21Case History: Discovery and Development of Verquvo® (Vericiguat), a Soluble Guanylate Cyclase (sGC) Stimulator for the Treatment of Chronic Heart Failure
Markus Follmann, Corina Becker, Lothar Roessig, Peter Sandner, and Johannes-Peter Stasch
Chapter 22Case History: Corectim® (Delgocitinib), The First Topical JAK Inhibitor for The Treatment of Atopic Dermatitis
Makoto Shiozaki
Chapter 23New Chemical Entities Entering Phase III Trials in 2022
Matthew Condakes, Jennifer Jiang, David W. Lin, Rhiannon Thomas-Tran, Juan del Pozo, Christiana N. Teijaro
Chapter 24To Market, to Market—2022: Small Molecules
Erika Araujo, Ian M. Bell, Alexander Burckle, Dennis C. Koester, James R. Manning, Georgette Castanedo, Mingshuo Zeng, T. G. Murali Dhar, Natalie Holmberg-Douglas, Eric R. Welin, J. Robert Merritt, Kevin M. Peese, Joanne J. Bronson
Chapter 25To Market, to Market—2022: Macromolecular Therapeutics
Shion A. Lim, Nicholas J. Agard, Ryan L. Kelly, Benjamin N. Bell, Si-Jie Chen, Anna M. Gram, J. Robert Merritt, Ian Moench, Katarina Pance, Tatjana Petojevic