2020 Medicinal Chemistry Reviews

Volume 55, Chapter 25
Case History: Eucrisa® (Crisaborole Ointment, 2%), A Boron-Based PDE4 Inhibitor for the Topical Treatment of Atopic Dermatitis
Matthew A. Perry

1. Introduction
2. Pathophysiology of Atopic Dermatitis and the Role of PDE4
3. Medicinal Chemistry Efforts Leading to the Discovery of Crisaborole
4. Preclinical Pharmacological Characterization of Crisaborole
5. Clinical Data on Eucrisa®
6. Conclusions

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