2020 Medicinal Chemistry Reviews

Volume 55, Chapter 24
Case History: Tpoxx® (Tecovirimat)—A Novel Orthopoxvirus Egress Inhibitor for the Treatment of Smallpox
Robert Jordan, Doug Grosenbach, James Burgeson, Dennis Hruby

1. Introduction
2. Smallpox Disease
3. Discovery of Tecovirimat
4. CMC and Safety Pharmacology
5. Early Clinical Studies
6. Registrational Studies under the “Animal Efficacy Rule”
7. Conclusion

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