2020 Medicinal Chemistry Reviews

Volume 55, Chapter 10
Clinical and pre-clinical approaches to the inhibition of KRASG12C
Brian A. Lanman, Victor J. Cee, Matthew A. Marx

1. Introduction
2. Screening Approaches to Identify Covalent Inhibitor Leads
3. Clinical Candidates, Preclinical Programs, and Patent Disclosures
4. Emerging Approaches
5. Clinical Findings
6. Conclusions

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