2019 Medicinal Chemistry Reviews

Volume 54, Chapter 18
Development of Small Molecules to Modulate the Activity of the ATP-Dependent ClpP Protease as a Novel Antibacterial and Anticancer Drug Target
Funing Lin, Mark F. Mabanglo, Walid A. Houry, Robert A. Batey

1. Introduction
2. ClpP Protease: Structure and Mechanism of Action
3. Inhibition of ClpP Protease
4. Activation of ClpP Protease
5. Targeting of AAA+ ClpP Unfoldases
6. Conclusions

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