2019 Medicinal Chemistry Reviews

Volume 54, Chapter 12
Exploiting Penicillin-Binding Protein-Mediated Inhibition of Cell Wall Biosynthesis for the Treatment of Bacterial Infections
Bin Liu, Jodie Hamrick, Denis M. Daigle, Stephen M. Condon

1. Introduction
2. Recent Progress Towards Boronate-Based β-Lactamase Inhibitors and Penicillin-Binding Protein Inhibitors
3. New Diazabicyclooctane-Based Inhibitors
4. Siderophore β-Lactam Conjugates
5. Other Clinical Results
6. Conclusions

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ACS Division of Medicinal Chemistry

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