2019 Medicinal Chemistry Reviews

Volume 54, Chapter 11
The Evolution of NNRTIs Leading to Doravirine (PIFELTRO®)
Abdellatif El Marrouni, Christopher S. Burgey

1. Introduction
2. Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)
3. Limitations of Previous NNRTIs
4. Medicinal Chemistry Efforts Leading to Doravirine
5. Doravirine Early Clinical Profile: ADME, PK-PD, and Tolerability
6. Clinical Trials of Doravirine
7. Future Directions
8. Conclusions

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