2019 Medicinal Chemistry Reviews

Volume 54, Chapter 5
Recent Advances in the Discovery and Development of Interleukin Receptor Associated Kinase 4 (IRAK4) Inhibitors
Jeromy Cottell, Nathan E. Wright, Matthew Warr, James G. Taylor

1. Introduction
2. IRAK4 Role in Inflammatory and Oncology Diseases
3. Scope and Strategy of Review
4. IRAK4 Protein Structure and Key Amino Acids Involved in Small-Molecule Interactions
5. Recent Advances in Medicinal Chemistry
6. Preclinical In Vivo Efficacy Studies
7. Clinical Trials with IRAK4 Inhibitors
8. Conclusions

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