2019 Medicinal Chemistry Reviews


Volume 54
Joanne J. Bronson, Editor-In-Chief

Medicinal Chemistry Reviews is an outstanding 680 page volume providing timely and critical reviews of important topics in medicinal chemistry. It is provided free of charge to MEDI members in electronic format. Members can also order a print copy, for the cost of printing, shipping and handling (US, $35; International, $60).    

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Table of Contents:

Chapter 1 A Love of Chemistry and My Career in Drug Discovery Research.
Bruce E. Maryanoff
Chapter 2 Small-Molecule Approaches for the Treatment of Sickle Cell Disease.
Zhe Li, Mira Patel, Donna Oksenberg, Brian Metcalf
Chapter 3 New Progress in Protease-Activated Receptor 1 and 4 (Par-1 and Par-4) Antagonists as Antiplatelet Therapy for Treatment Cardiovascular Disease
Xiaojun Zhang
Chapter 4 Recent Advances in the Development of Small-Molecule Inhibitors for Idiopathic Pulmonary Fibrosis (IPF).
Katerina Leftheris, Yajun Zheng, Timothy D. Machajewski
Chapter 5 Recent Advances in the Discovery and Development of Interleukin Receptor Associated Kinase 4 (IRAK4) Inhibitors
Jeromy Cottell, Nathan E. Wright, Matthew Warr, James G. Taylor
Chapter 6 Untangling Perception and Reality: Small-Molecule TNF-α Inhibitors
Jeremy J. Edmunds
Chapter 7 IDH Inhibitors for the Treatment of IDH-Mutated Cancer
Lenny Dang, Brandon Nicolay, Zenon Konteatis
Chapter 8 Recent Advances in DHODH Inhibition for Acute Myeloid Leukemia
Scott D. Kuduk, Justin S. Cisar, E. Christine Pietsch
Chapter 9 STING Agonists for Immuno-Oncology
Thorsten Oost, Christian A. Kuttruff, Herbert Nar
Chapter 10 The Discovery of Manogepix/Fosmanogepix and Other Gwt1 Inhibitors for the Treatment of Invasive Fungal Infections
Jonathan A. Covel, Quinlyn A. Soltow, Mili Kapoor, Molly K. Moloney, Peter J. Webb, Michael Trzoss, Marc Sharp, Karen Joy Shaw
Chapter 11 The Evolution of NNRTIs Leading to Doravirine (PIFELTRO®)
Abdellatif El Marrouni, Christopher S. Burgey
Chapter 12 Exploiting Penicillin-Binding Protein-Mediated Inhibition of Cell Wall Biosynthesis for the Treatment of Bacterial Infections
Bin Liu, Jodie Hamrick, Denis M. Daigle, Stephen M. Condon
Chapter 13 Small-Molecule Therapeutics Targeting RNA
Justin T. Ernst, Christian Nilewski, Peggy Thompson, Craig Stumpf
Chapter 14 Recent Applications of Covalent Chemical Probes for Investigating Drug Off-Target Engagement
Christopher W. am Ende, Jaimeen D. Majmudar, Ralph P. Robinson
Chapter 15 Predicting Human Brain Exposure: Recent Advancements Integrating In Vitro, In Silico and Preclinical Data
Nandini C. Patel
Chapter 16 Design and Tactical Applications of Prodrugs to Enable Effective Drug Delivery
Murugaiah A. M. Subbaiah, Nicholas A. Meanwell
Chapter 17 Advances in the Development of Deubiquitinase (DUB) Inhibitors
Jian Wu, Xu Wang, Kumar Suresh
Chapter 18 Development of Small Molecules to Modulate the Activity of the ATP-Dependent ClpP Protease as a Novel Antibacterial and Anticancer Drug Target
Funing Lin, Mark F. Mabanglo, Walid A. Houry, Robert A. Batey
Chapter 19 Case History: DaurismoTM (Glasdegib), for the Treatment of Patients with Acute Meyloid Leukemia
Nandini C. Patel, Michael J. Munchhof
Chapter 20 Case History: Talzenna® (Talazoparib)—A Highly Potent, Orally Efficacious PARP Inhibitor for the Treatment of BRCA-Mutated, HER2-Negative Breast Cancer Patients
Bing Wang, Yuqiao Shen, Leonard E. Post
Chapter 21 New Chemical Entities Entering Phase III Trials in 2018
Adam J. Schrier, Nathan E. Wright, David W. Lin, Vickie Tsui, Gregory T. Notte, Amy S. Lee
Chapter 22 To Market, to Market—2018: Small Molecules
Erika Araujo, Marie-Gabrielle Braun, Peter S. Dragovich, Antonella Converso, Philippe G. Nantermet, Anthony J. Roecker, T. G. Murali Dhar, Pamela Haile, Anna Hurtley, J. Robert Merritt, Kevin M. Peese
Chapter 23 To Market, to Market—2018: Biologics
Catherine A. Bolger, Suzana A. Kahn, Daša Lipovšek, William Mallet, James Wieler

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