Medicinal Chemistry Reviews

Volume 52, Chapter 25

Case History:  Zurampic® (Lesinurad):  A Selective Uric Acid Reabsorption Inhibitor for the Treatment of Hyperuricemia in Gout Patients

Jean-Luc Girardet and Barry D. Quart

1.          Introduction                                                                                                               485

2.         Mechanisms of the Disease                                                                                     486

3.         Discovery of Lesinurad                                                                                             488

4.         Scale-up Process Development                                                                                489

5.         Path to Regulatory Approval                                                                                   490

6.         Conclusion                                                                                                                 492

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