Medicinal Chemistry Reviews

Volume 52, Chapter 24

Drug-Induced Liver Injury (DILI) Arising from Inhibition of Bile Acid Transport Proteins

Michael D. Aleo, Deepak Dalvie, and Amit S. Kalgutkar

1.          Introduction                                                                                                               465

2.         BSEP Deficiency and DILI                                                                                         466

3.         Inhibition of BA Transport as a Causative Factor for DILI                                     467

4.         Physicochemical Characteristics and Structure-Toxicity Relationships                470

            4.1        Nontricyclic Antidepressants                                                                       473

            4.2       Thiazolidinediones                                                                                       473

            4.3       Endothelial Receptor Antagonists (ERAs)                                                   475

5.         Prediction of DILI Risk                                                                                              477

6.         Conclusion                                                                                                                 479

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