Medicinal Chemistry Reviews

Volume 52, Chapter 22

Repositioning Strategies that Target Remyelination for the Treatment of Multiple Sclerosis

Stefania Risso, Robert L. Hudkins, Peter H. Hutson, and Dmitri Leonoudakis

1.          Introduction                                                                                                               423

2.         In Vitro Functional Screening of Remyelination                                                     425

            2.1        Phenotypic Assays of Remyelination                                                         426

3.         Targets and Repositioning Drugs for Remyelination                                            427

            3.1        Muscarinic Antagonists                                                                                 427

            3.2       Dopamine Modulators                                                                                 429

            3.3       Kappa Opioid Receptor Agonists                                                    431

            3.4       Endocannabinoid Ligands                                                                           432

            3.5       PDE7 Inhibitors                                                                                             434

            3.6       PPAR Receptor Agonists                                                                               434

            3.7       Miscellaneous Targets and Drugs                                                    435

4.         Conclusion                                                                                                                 437

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