Medicinal Chemistry Reviews

Volume 52, Chapter 14

Small-Molecule Antagonists of Mcl-1

Joshua P. Taygerly and Daniel W. Robbins

1.          Introduction                                                                                                               263

2.         Small-Molecule Selective Mcl-1 Antagonists                                                            266

            2.1        AMG 176                                                                                                         266

            2.2       S63845                                                                                                           267

            2.3       AZD5991                                                                                                         269

            2.4       Indole-2-carboxylate Inhibitors                                                                   270

            2.5       Indole-2-(methylsulfonyl)carboxamide Inhibitors                                                 272

            2.6       Arylboronic Acid Covalent Inhibitors                                                          273

            2.7       Cyclopeptidic Inhibitors                                                                               274

3.         Conclusions                                                                                                               275

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