Medicinal Chemistry Reviews

Volume 52, Chapter 12

Small Molecules for Cancer Immunotherapy

Timothy P. Heffon and Bryan K. Chen

1.          Introduction                                                                                                               221

2.         IDO and TDO Enzymes                                                                                              222

3.         Toll-Like Receptors                                                                                        223

4.         Adenosine Pathway                                                                                     224

5.         Arginine Metabolism                                                                                                226

6.         PGE2                                                                                                                           227

7.         Chemokines and Chemokine Receptors                                                                227

            7.1        CXCR1/CXCR2                                                                                     228

            7.2       CXCR4                                                                                                 229

            7.3       CCR5                                                                                                               230

            7.4       CCR2                                                                                                               230

            7.5       CCR4                                                                                                               231

8.         Kinases                                                                                                                       232

9.         Conclusion                                                                                                                 234

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