Medicinal Chemistry Reviews

Volume 52, Chapter 10

Diverse Drugs with Gastrointestinal-Restricted Delivery

Thomas D. Aicher, Clarke B. Taylor, and Peter L. Toogood

1.          Introduction                                                                                                               179

2.         Ileal Bile Acid Transporter (IBAT) Inhibitors                                                           180

3.         TGR5 Agonists                                                                                                            182

4.         Pan JAK Inhibitors                                                                                                    183

5.         “Narrow Spectrum” Tyrosine Kinase Inhibitors                                                     184

6.         RET Kinase Inhibitors                                                                                                185

7.         α4-β7 Integrin Antagonist (PTG-100)                                                                       185

8.         NHE3 Inhibitors                                                                                                         187

9.         F1F0-ATPase Modulator                                                                                             188

10.        Summary/Lessons Observed                                                                                    189

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