Medicinal Chemistry Reviews

Volume 52, Chapter 9

Recent Advances in the Discovery of CSFqR Inhibitors for Autoimmune Diseases

Dawn M. George, Michael Hoemann, and Jacqueline Loud

1.          Introduction                                                                                                               165

            1.1        CSF1R as an Immunological Target                                                  165

            1.2        Role in Disease Pathology                                                                           166

            1.3        Potential Concerns Associated with Inhibition                                         167

2.         Recent Small-Molecule CSF1R Inhibitors                                                     168

            2.1        Heteroarylamides                                                                                          168

            2.2       Amidoquinolines and Amidocinnolines                                                     170

            2.3       Other Chemotypes                                                                                        171

3.         Clinical Data                                                                                                               173      

4.         Conclusions                                                                                                               174

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