Medicinal Chemistry Reviews

Volume 52, Chapter 8

Glucokinase Activators for the Treatment of Diabetes

Paul Dransfield

1.          Introduction                                                                                                               147

            1.1        Introduction to Diabetes                                                                              147

            1.2        Glucokinase                                                                                                    147

2.         Glucokinase Activators                                                                                              149

            2.1        Background                                                                                                    149

            2.2       Selected GKA Publications Prior to 2014                                                     150

            2.3       Selected GKA Publications After 2014                                                          153

                        2.3.1     Liver-Selective GKAs                                                              153

                        2.3.2    Novel “Carbon-Centered” GKAs                                                      154

                        2.3.3    Novel “Aromatic-Centered” GKAs                                                   154

3.         Conclusions                                                                                                               157

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