Medicinal Chemistry Reviews

Volume 52, Chapter 7

Development of Sodium-Dependent Phosphate Co-Transporter 2b Inhibitors for Treatment of Hyperphosphatemia

Yanping Xu and Dariusz Wodka

1.          Introduction                                                                                                               125

2.         Early Discovery of Intestinal Sodium-Dependent Phosphate 

            Transporter Inhibitors                                                                                              127

3.         Investigation of Sodium-Dependent Phosphate Co-Transporter 2b

 Inhibitors                                                                                                                  130

            3.1        Triazoles                                                                                                         131

            3.2       Acylhydrazones                                                                                             132

            3.3       Thiophene Amides                                                                                        133

            3.4       Anthranilic Amides and Related Analogs                                                   136

            3.5       Dihydropyridazine-3,5-diones                                                                     141

4.         Clinical Studies and Future Perspectives                                                     142

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