Medicinal Chemistry Reviews

Volume 52, Chapter 5

Recent Advances in BACE1 Biology and Inhibitors in Clinical Development

1.          Introduction                                                                                                               89

2.         BACE1 and the Amyloid Hypothesis                                                                        90

3.         Safety and Tolerability of BACE Inhibition                                                             91

            3.1        Bace1 Knockout Mice                                                                                    91

            3.2       Bace2 Knockout Mice                                                                                    92

            3.3       Cathepsin D                                                                                                   93

4.         Compounds in Advanced Clinical Development                                                   94

            4.1        Verubecestat                                                                                      94

            4.2       Lanabecestat, Elenbecestat, JNJ54861911, CNP520                                   97

5.         Conclusions                                                                                                               101

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