Medicinal Chemistry Reviews

Volume 52, Chapter 2

PDE1 Inhibition:  Potential for the Treatment of Cognitive Impairment 

1.          Introduction                                                                                                               25

2.         Vinpocetine and Early Non-Selective PDE1 Inhibitors                                           28

3.         Recent Medicinal Chemistry and Pharmacology of Selective PDE1 Inhibitors  29

4.         PDE1 Structural Biology                                                                                             33

5.         Patent Landscape                                                                                                     35

            5.1        Fused 6,5-Bicyclic Rings                                                                                35

            5.2       Fused 6,6-Bicyclic Rings                                                                                37

            5.3       Fused Tricyclic Rings                                                                         37

6.         Conclusions                                                                                                               38

To purchase a copy, contact secretary@acsmedchem.org

ACS Division of Medicinal Chemistry

Webmaster:  secretary@acsmedchem.org