Medicinal Chemistry Reviews

Volume 51, Chapter 3

Metabotropic Glutamate Receptors at Thirty:  New Insights From Chemical Tools Enabling Mechanistic Understanding

1.    Introduction                                                                                                                    37   

2.   Group 2 mGluR Activation                                                                                                  39

      2.1        mGluR2/3 Agonists                                                                                                  39

      2.2 mGluR2 Positive Allosteric Modulators                                                                       40

3.   Group 2 mGluR Modulation                                                                                                41

      3.1        mGluR5 Positive Allosteric Modulators                                                           42

      3.2 mGluR5 Negative Allosteric Modulators                                                                     44

      3.3 mGluR1 Positive Allosteric Modulators                                                                       45

4.   Group 3: mGluR4 Receptor Activation                                                                               46

      4.1        mGluR4 Positive Allosteric Modulators                                                          46

      4.2 mGluR4 Agonists                                                                                                           47

      4.3 Group 3 mGluR Pan-PAMs                                                                                            48

5.   Conclusions                                                                                                                         49

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