Medicinal Chemistry Reviews

Volume 51, Chapter 2

Recent Developments in Neuropeptide S Receptor (NPSR) Research

1.    Introduction                                                                                                                17   

2.   Single-Nucleotide Polymorphism (SNP)                                                                           18

      2.1        SNP (rs324981) and Anxiety Disorders                                                                 18

      2.2 SNP (rs324981) and Alcohol Use                                                                                 20

      2.3 SNP (rs324981) and Sleep Regulation                                                                          21

      2.4 SNP (rs324981) and Influence of Urban Upbringing on Stress                                22

      2.5 SNP (rs4751440) Originated from Europe Shows Decreased Bioactivity                 23

3.   Identification of Intracellular Pathways Activated Following NPSR1

      Stimulation in Neurons                                                                                                      23

4.   Antinociception: Anxiolytic and Pain-Inhibiting Effects of NPS                                    24

5.   Role of NPS in Fear Extinction, Extinction Memory, and Object

     Recognition Memory                                                                                                          26

6.   NPS and Social Aggression in Mice                                                                                   26

7.   NPS as Biomarker in Cancer                                                                                              28

8.   NPS, Cytokines, and Inflammation                                                                                   28

9.   Evolution of the NPS Receptor                                                                                          28

10. Novel Ligands for NPSR                                                                                                     29

11. Conclusions                                                                                                                          31

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