Medicinal Chemistry Reviews

Volume 50, Chapter 19
To Market, To Market--2014
Joanne Bronson, Kevin Peese, Amelia Black, Murali Dhar, Achal Pashine, Bruce A. Ellsworth, and J. Robert Merritt

A review of 47 compounds that received approval for the first time in 2014.

1.    Albiglutide (Antidiabetic)                                                                                           473

2.   Alectinib (Anticancer)                                                                                                 475

3.   Apatinib (Anticancer)                                                                                                 477

4.   Aprelimast (Antiarthritis)                                                                                           478

5.   Asunaprevir (Antiviral)                                                                                               480

6.   Ataluren (Duchenne Muscular Dystrophy)                                                               482

7.   Belinostat (Anticancer)                                                                                               484

8.   Blinatumomab (Anticancer)                                                                                       486

9.   Ceftolozane (Antibacterial)                                                                                        488

10. Ceritinib (Anticancer)                                                                                                  489

11. Daclatasvir (Antiviral)                                                                                                 491

12. Dalbavancin (Antibacterial)                                                                                        494

13. Dasabuvir (Antiviral)                                                                                                   496

14. Delamanid (Antibacterial)                                                                                          498

15. Dulaglutide (Antidiabetic)                                                                                           500

16. Eliglustat (Gaucher Disease)                                                                                        502

17. Empagliflozin (Antidiabetic)                                                                                       504

18. Favipiravir (Antiviral)                                                                                                  505

19. Finafloxacin (Antibacterial)                                                                                        507

20.Fluocinolone acetonide (Diabetic Macular Edema)                                                  508

21. Idelalisib (Anticancer)                                                                                                 510

22.Ledipasvir (Antiviral)                                                                                                   512

23.Naloxegol (Constipation)                                                                                           515

24.Nemonoxacin (Antibacterial)                                                                                     516

25. Netupitant (Antiemetic)                                                                                             518

26. Nintedanib (Pulmonary Fibrosis, Idiopathic)                                                          520

27. Nivolumab (Anticancer)                                                                                             522

28. Olaparib (Anticancer)                                                                                                 524

29. Ombitasivir (Antiviral)                                                                                                525

30. Oritavancin (Antibacterial)                                                                                         528

31. Paritaprevir (Antiviral)                                                                                                530

32. Peginterferon beta-1A (Multiple Sclerosis)                                                               532

33. Pembrolizumab (Anticancer)                                                                                     533

34. Ramucirumab (Anticancer)                                                                                         535

35. Ripasudil (Antiglaucoma)                                                                                           537

36. Secukinumab (Antipsoriasis)                                                                                     538

37. Siltuximab (Castleman’s Disease)                                                                             541

38. Suvorexant (Sleep Disorders)                                                                                    543

39. Tasimelteon (Sleep Disorders)                                                                                  545

40. Tavaborole (Antifungal)                                                                                             546

41. Tedizolid phosphate (Antibacterial)                                                                          548

42. Tofogliflozin (Antidiabetic)                                                                                        550

43. Umeclidinium bromide (Chronic Obstructive Pulmonary Disorder)                      551

44. Vaniprevir (Antiviral)                                                                                                  553

45. Vedolizumab (Ulcerative Colitis)                                                                               555

46. Vonoprazan (Acid-related Gastric Diseases)                                                             558

47. Vorapaxar (Antiplatelet)                                                                                            560         

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ACS Division of Medicinal Chemistry

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