Medicinal Chemistry Reviews
Volume 50, Chapter 12
Fifty Five Years of Structural Biology: A Perspective on How Biophysics has Influenced Medicinal Chemistry
Mark C. Noe and Ravi G. Kurumbail
1. Introduction 299
1.1 Protein X-ray Crystallography 300
1.2 Protein NMR and Biophysical Methods 301
2. Case Studies of Structure-Based Drug Design 304
2.1 Proteases 304
2.2 Hydrolases 316
2.3 Protein Kinases 319
2.4 Other Enzymes 331
3. New Frontiers in Structural Biology and Drug Discovery 334
3.1 Fragment-Based Drug Discovery 334
3.2 Structural Biology of Macromolecular Assemblies: Prokaryotic
and Eukaryotic Ribosomes 336 3.3 Structural Biology of Integral Membrane Proteins: G-Protein Coupled Receptors 337
3.4 Structural Biology of Integral Membrane Proteins: Ion Channels 339
4. Conclusion 341
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