Medicinal Chemistry Reviews

Volume 50, Chapter 11
Targeting the Number Two Infectious Disease Killer--Tuberculosis
Hendra Gunosewoyo, Shichun Lun, William R. Bishai, and Alan P. Kozikowski

1.    Introduction                                                                                                                283

2.   New Additions to Clinical and Preclinical TB Drugs                                                284

3.   Optimization/Repurposing of Existing Drugs                                                           285

      3.1        Oxazolidinones                                                                                               285

      3.2       Rifampin analogs                                                                                            286

      3.3       Fluoroquinolones                                                                                           287

      3.4       Riminophenazines                                                                                          288

4.   New Chemical Entities from Phenotypic Screening                                                288

      4.1        Nitroimidazoles                                                                                               288

      4.2       Benzothiazinones and Other DprE1-targeting Compounds                        289

      4.3       MmpL3 Hitters                                                                                                290

      4.4       Imidazopyridine Amides and Caprazene Nucleoside 292

5.   Concluding Remarks                                                                                                   292

To purchase a copy, contact secretary@acsmedchem.org

ACS Division of Medicinal Chemistry

Webmaster:  secretary@acsmedchem.org