Medicinal Chemistry Reviews

Volume 50, Chapter 10
Anti-infective Drugs Through Medicinal Chemistry:  A 50-Year Retrospective
William J. Watkins and Jacob J. Plattner

1.    Introduction                                                                                                                242

2.   Antibacterials                                                                                                              243

      2.1        Penicillins                                                                                                        244

      2.2       β-Lactamase Inhibitors                                                                                   245

      2.3       Cephalosporins                                                                                               247

      2.4       Carbapenems                                                                                                  248

      2.5       Aminoglycosides                                                                                             249

      2.6       Quinolones                                                                                                      250

      2.7       Macrolides                                                                                                       252

      2.8       Oxazolidinones                                                                                               254

      2.9       Tetracyclines                                                                                                    255

      2.10      Glycopeptides                                                                                                 256

3.   Antivirals                                                                                                                      257

      3.1        Nucleosides and Nucleotides                                                                         259

      3.2       Non-nucleoside Inhibitors of HIV and HCV polymerases                           262

      3.3       HIV and HCV Protease Inhibitors                                                                  263

      3.4       HIV Integrase Inhibitors                                                                                 266

      3.5       HCV NS5A Inhibitors                                                                                       267

      3.6       Influenza Neuraminidase Inhibitors                                                              268

4.   Antifungals                                                                                                                  269

      4.1        Polyenes                                                                                                          269

      4.2       Azoles                                                                                                               271

      4.3       Candins                                                                                                            272

5.   Antiparasitics                                                                                                               273

      5.1        Antimalarials                                                                                                   273

6.   Conclusions                                                                                                                 277

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