Medicinal Chemistry Reviews

Volume 50, Chapter 8
Progress into the Era of Genomically Targeted Cancer Drugs:  50 Years of Anticancer Medicinal Chemistry
Paul W. Manley, Philipp Holzer, Henrik Möbitz, Philip R. Skaanderup, and Frédéric Stauffer

1.    Introduction                                                                                                                187

2.   Anticancer Drugs Targeting Protein Kinases                                                            190

3.   Anticancer Drugs Targeting Lipid Kinases                                                                199

4.   Anticancer Drugs Targeting Protein-Protein Interactions Regulating Apoptosis  203

5.   Anticancer Drugs Targeting Deregulated Epigenetic Pathways                              208

      5.1        Agents Targeting Aberrant DNA Methylation                                              208

      5.2       Agents Targeting Histones                                                                             209

6.   Drugs Addressing Other Targets                                                                                212

      6.1        Hormones and Hormone Receptors                                                             212

      6.2       RAS                                                                                                                   213

7.   Summary and Outlook                                                                                               214

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