Medicinal Chemistry Reviews

Volume 50, Chapter 5
Recent Developments in HIF Prolyl Hydroxylase Inhibitors
Vrajesh B. Pandya, Amit A. Joharapurkar, Mukul R. Jain, and Ranjit C. Desai

1.    Introduction                                                                                                                119

2.   Therapeutic Potential of HIF Prolyl Hydroxylase Inhibitors                                   120

3.   Inhibitors of HIF Prolyl Hydroxylases                                                                       121

      3.1        Glycinamide-Based Carboxylic Acids                                                            121

      3.2       Non-glycine Carboxylic Acids                                                                        123

      3.3       Non-carboxylic Acids                                                                                      124

      3.4       Isoform-Selective PHD Inhibitors                                                                  127

4.   Clinical Update                                                                                                            129

5.   Conclusions                                                                                                                 130

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