Medicinal Chemistry Reviews

Volume 50, Chapter 3
Recent Advances on the Inhibition of Endocannabinoid Hydrolysis
Michael K. Ameriks, Nicholas I. Carruthers, and James A. Palmer

1.    Introduction                                                                                                                63

2.   Endocannabinoid Metabolism                                                                                  64

3.   FAAH   65

      3.1        Biology                                                                                                             65

      3.2       Inhibitors                                                                                                     65           

4.   MGL                                                                                                                              69

      4.1        Biology                                                                                                        69           

      4.2       Inhibitors                                                                                                     69           

5.   Dual MGL/FAAH Inhibitors                                                                                         72

6.   ABHD6 Inhibitors                                                                                                        73

7.   ABHD12 Inhibitors                                                                                                       74

8.   Conclusions                                                                                                                 75

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