| |
Dr. Burton G. Christensen was born in Waterloo, Iowa (April
8, 1930) and received his B.Sc. degree in chemistry from Iowa
State University (1952) followed by his A.M. and Ph.D. degrees
(1956) in organic chemistry from Harvard University. He went
directly to the Merck Research Laboratories of Merck &
Co., Inc., where his final positions was Senior Vice President,
Chemistry, directing ongoing basic research on human, animal
health, and agricultural chemical projects, as well as being
responsible for the scientific direction of the Merck Frosst
Laboratories.
His early research was in the areas of diazoketone, steroid
and heterocyclic chemistry. However, since about 1965 his
interests have been concentrated in antibiotic chemistry.
Before 1970 his most notable work was concerned with the structural
elucidation, synthesis and analog syntheses of the antibiotic
fosfomycin (phosphonomycin). In later work at Merck, Dr. Christensen’s
focus was in the area of ß-lactam antibiotics. The total
syntheses of the penicillins, cephalosporins, cephamycins
and carbapenems (especially thienamycin) were all completed
at Merck under his direction. The commercial products, Mefoxin®
(cefoxitin) and Primaxin® (imipenem, cilastatin), resulted
from this research. As part of the nuclear analog program,
oxacephalosporins, carbacephalosporins and 1α-methylcarbapenems
were first synthesized at Merck.
Groups reporting to Dr. Christensen have also synthesized
ivermectin (Ivomec®), the world's largest selling animal
health product, PedvaxHIB®, a conjugate vaccine for the
prevention of H. influenza and Proscar® (finasteride),
a 5α-reductase inhibitor for the treatment of benign
prostatic hypertrophy. Several other products in the immunology,
antimicrobial, cardiovascular and respiratory areas also entered
development.
After taking early retirement from Merck in July, 1992, he became a member
of the Scientific Advisory Boards of Microcide Pharmaceuticals,
Neurocrine Biosciences, Onyx Pharmaceuticals, Pharmacopeia
and Aurora Biosciences and also served as a consultant for
Amgen and Genetics Institute. He then co-founded and assumed
a full-time position as Executive Vice President, Research,
of Advanced Medicine, Inc. (now Theravance, Inc.) During his
tenure there, Televancin®, a gram-positive antibacterial
agent now awaiting world-wide approval, was synthesized and
several other products have since demonstrated efficacy in
clinical trials.
He is currently a consultant for Theravance, Inc., Vitae Pharmaceuticals,
PharmacoFore, Achaogen, Ensemble Discovery Corp. and Genentech.
In 2004, he also served as interim Chief Scientific Officer
of Infinity Pharmaceuticals, Inc. during the search for a
permanent CSO.
Dr. Christensen has been invited to deliver plenary lectures
at over 50 International Symposia and is author of 79 scientific
papers and 181 issued U.S. Patents. He also serves on the
editorial advisory boards of Medicinal Chemistry and the Journal
of Antibiotics. He delivered the Sixth Cecile L. Brown lecture
(1974-NJACS) and received the Thomas Alva Edison Patent Award
(1985), Merck Directors Scientific Award (1987), Chemical
Pioneers Award (1989-AIC) and was elected a Fellow of the
AAAS (1996). He also served on the visiting committees of
both the Harvard and MIT chemistry departments.
|
 |