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Ronald T. Borchardt is the Solon E. Summerfield Distinguished
Professor of Pharmaceutical Chemistry at The University of
Kansas- Lawrence. Professor Borchardt received his undergraduate
education (B.S. in Pharmacy, 1967) from the University of
Wisconsin-Madison and his graduate education (Ph.D. in Medicinal
Chemistry, 1970) from The University of Kansas-Lawrence. After
serving as a Postdoctoral Fellow at the National Institutes
of Health (Bethesda, Maryland) from 1969-1971, Professor Borchardt
returned to The University of Kansas as an Assistant Professor.
In the 1970's Professor Borchardt was promoted through the
academic ranks to his current position as Solon E. Summerfield
Distinguished Professor. From 1983-1998, Professor Borchardt
served as the Chairman of the Department of Pharmaceutical
Chemistry in the School of Pharmacy at The University of Kansas.
During his academic career, Professor Borchardt supervised
the research of approx. 170 graduate students, postdoctoral
fellows and visiting scientists.
Professor Borchardt’s research interests include both
drug delivery and drug design. In the area of drug delivery,
his interests include: (i) the development of epithelial and
endothelial cell culture systems for the study of drug transport
and metabolism; (ii) the development of rational strategies
(e.g. prodrugs) to improve the transport characteristics of
peptides and peptidomimetics; (iii) the elucidation of the
chemical pathways of protein and peptide degradation; and
(v) the development of strategies to stabilize biomolecules
in pharmaceutical formulations. Professor Borchardt’s
interest in drug design has focused on the design and synthesis
of inhibitors of an enzyme (S-adenosylhomocysteine hydrolase)
that plays a key role in regulating biological methylation
reactions, which are crucial for the replication of some viruses
and parasites.
Professor Borchardt contributions to the development and validation
of cell cultures for studying drug transport across the intestinal
mucosa and the blood-brain barrier have been particularly
significant. His pioneering work in the late 1980s lead to
the introducing of Caco-2 cells as a model of the intestinal
mucosa. This cell culture model is now widely used by scientists
in pharmaceutical/biotechnology companies and in academic
and government laboratories worldwide. Based upon his medicinal
chemistry background, Professor Borchardt has more recently
utilized this in vitro cell culture model for studying how
structure influences transport of drugs across the intestinal
mucosa.
During his academic career Professor Borchardt has received
numerous awards and honors for his teaching and research accomplishments
including: Established Investigator from the American Heart
Association (1974-1979); Sato Memorial International Award
from the Pharmaceutical Society of Japan (1981); Mortar Board
Outstanding Educator Award (1980), Dolph C. Simons, Sr. Research
Award in the Biomedical Sciences (1983), the Louise Byrd Graduate
Educator Award (1997) and the Chancellors Club Career Teaching
Award (2005) from The University of Kansas; Fellow of the
American Association of Pharmaceutical Scientists (1988) and
the American Association for the Advancement of Science (1995);
Citation of Merit from the University of Wisconsin (1989);
Meritorious Manuscript Awards (1991, 1998), Research Achievement
Awards in Biotechnology (1993) and Medicinal Chemistry (1994),
and Distinguished Pharmaceutical Scientist Award (1997) from
the American Association of Pharmaceutical Scientists; Takeru
and Aya Higuchi Memorial Lectureship Award from the Academy
of Pharmaceutical Sciences and Technology of Japan (1993);
Paul Dawson Biotechnology Award (1997) and Volwiler Research
Achievement Award (1998) from the American Association of
Colleges of Pharmacy; Hoest-Madsen Medal (1999) from the International
Pharmaceutical Federation; Distinguished Service Award (1999)
from the FASEB Research Conference on Biological Methylation;
the Millennial Pharmaceutical Scientist Award (2000) from
the Millennial World Congress of Pharmaceutical Sciences;
the Research Achievement Award in the Pharmaceutical Sciences
(2001) and the Takeru Higuchi Research Prize (2003) from the
American Pharmaceutical Association; the Smissman-Bristol-Myers
Squibb Award from the Medicinal Chemistry Division of the
American Chemical Society (2003); PolyPops Foundation Award
from the Society for Biomolecular Sciences (2007); and Honorary
Doctorate Degrees from The Danish University of Pharmaceutical
Sciences, Copenhagen, Denmark (2002), Katholieke University,
Leuven, Belgium (2004) and Uppsala University, Uppsala, Sweden
(2006).
Professor Borchardt is the author or co-author of approximately
495 scientific publications and 460 abstracts. He is also
the Editor of 10 books, and the Series Editor of "Pharmaceutical
Biotechnology" (14 published volumes, Springer) and “Biotechnology:
Pharmaceutical Aspects” (7 published volumes, AAPS Press/Springer).
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